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Abbreviations BSI Bloodstream infection CABSI Laboratory confirmed bloodstream infection CHG Chlorhexidine-gluconate impregnated discs CRBSI Catheter-related bloodstream infections CSD Combination securement dressing CVADs Central venous access devices HREC Human Research Ethics Committee PAL Polyurethane with absorbent lattice pad PICCs Peripherally inserted central catheters RBWH Royal Brisbane and Women’s Hospital RCT Randomised controlled trial REDCap Research Electronic Data CAPture ReNs Research Nurses SPU Standard polyurethane dressing SSD Sutureless securement device TA Tissue adhesive Authors’ contributions All authors (RC, SN, EL, GM, AU, PH, NM, DW, AA, ER, MAC, JF, and CRM) contributed to the design of the study

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